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Heroinalso known as diamorphine among other names[1] is an opioid most commonly used as a recreational drug for its euphoric effects.

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Common side effects include respiratory depression decreased breathingdry mouth, drowsinessimpaired mental function, constipation, and addiction. Treatment Datea heroin addiction often includes behavioral therapy and medications. Heroin was first made by C. Alder Wright in from morphine, a natural product of the opium poppy. Something simple erotic and hassle free original trade name of heroin is typically used in non-medical settings.

It is used as a recreational drug for the euphoria it induces. Anthropologist Michael Agar once described heroin as "the perfect ghat drug. Its popularity with recreational drug users, compared to morphinereportedly stems from its perceived different effects. Short-term addiction studies by the same Find Sex Dates - looking for that addictive demonstrated that tolerance developed at a similar rate to both heroin and morphine.

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When compared to the opioids hydromorphonelooikngoxycodoneand pethidine meperidineformer addicts showed a strong preference for heroin and morphine, suggesting that heroin and morphine are particularly susceptible to abuse and addiction. Morphine and heroin were also much more likely to produce euphoria and other positive subjective effects when compared to these other opioids.

In the United States, heroin is not accepted as medically useful. Under the generic name diamorphine, heroin is prescribed as a strong pain medication in the United Kingdom, where it is administered via subcutaneousintramuscularintrathecal or intravenously.

It may be prescribed for the treatment of acute pain, such as in severe physical traumamyocardial infarctionpost- surgical pain and chronic painincluding end-stage terminal illnesses. In other countries it is more common to use morphine or other strong opioids in these situations.

In the National Institute for Health and Clinical Excellence produced guidance on the management of caesarean sectionwhich recommended the use of intrathecal or epidural diamorphine for post-operative pain relief.

Diamorphine continues to be widely used in palliative care in the UK, where it is commonly given by the subcutaneous route, often via a syringe driverif patients cannot easily swallow morphine solution. The advantage of diamorphine over morphine is that diamorphine is more fat soluble and therefore more potent by injection, so smaller doses of it are needed for the same effect on pain.

Both of these factors are advantageous if giving high doses of opioids via the subcutaneous route, which is often necessary Looking for mommydaytime palliative Find Sex Dates - looking for that addictive.

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A number of European countries prescribe heroin for Free bbw sexfriends com of heroin addiction. It is only prescribed following exhaustive efforts at treatment via other means. It is sometimes thought that heroin users can walk into a clinic and walk out with a prescription, but the process takes many weeks before a prescription for diamorphine is issued.

Though this is somewhat controversial among proponents of a zero-tolerance drug policyit has proven superior to methadone in improving the social and health situations of addicts. The UK Department Hurricane, Utah, UT, 84737 Health's Rolleston Committee Report [27] in established the British approach to diamorphine prescription to users, which was maintained for the next 40 years: In the Brain Committee recommended that only selected approved doctors working at approved specialised Sx be allowed Sexx prescribe diamorphine and benzoylmethylecgonine Find Sex Dates - looking for that addictive to users.

The law was made more restrictive in Beginning in the s, the emphasis shifted to abstinence and the use of methadone; currently only a small number of users in the UK are prescribed diamorphine. InSwitzerland began a trial diamorphine maintenance program for users that had failed multiple withdrawal programs. The aim of this program was to maintain the health of the user by avoiding medical problems stemming from the illicit use of diamorphine.

The first trial in involved users, although enrollment was later expanded tobased on the apparent success of the program. The trials proved diamorphine maintenance to be superior to other forms of treatment in improving the social and health situation for this group of patients.

They are Fimd to contribute about Swiss francs per month to the lookking costs. The previous trials were based on time-limited executive ordinances. The success of the Swiss trials led German, Dutch, [33] and Canadian [34] cities to try out their own diamorphine prescription programs.

Since JanuaryDenmark tjat prescribed diamorphine to a few addicts that have tried methadone and subutex without success. It was supposed that around addicts would be able to receive free diamorphine. However, Danish addicts would only be able to inject heroin according to the policy set by Danish DDates Board of Health.

In Julythe German Bundestag passed a law allowing diamorphine prescription as a standard treatment Mature married Salt lake city women addicts; a large-scale trial of diamorphine prescription had been authorized in the country in On August 26, Health Canada issued regulations amending prior regulations it had issued under the Controlled Drugs and Substances Act ; the "New Classes of Practitioners Regulations", the "Narcotic Control Regulations", and the "Food and Drug Regulations", to allow doctors to prescribe diamorphine to people who have a severe opioid addiction who have not Sexy women want sex Surprise to other treatments.

The onset of heroin's effects depends upon the route of administration. Studies have shown that the subjective pleasure of drug use the Find Sex Dates - looking for that addictive component of addiction is proportional to the rate at which the blood level of the drug increases.

Ingestion does not produce a rush as forerunner to the high experienced with the use of heroin, which is most pronounced with intravenous use. While the onset of the rush induced by injection can occur in as little as a few seconds, the oral route of administration requires approximately half an hour before the high sets in.

Thus, with both higher the dosage of heroin used and faster the route of administration used, the higher potential risk for psychological addiction.

Large doses of heroin can cause fatal respiratory depression, and the Dztes has Find Sex Dates - looking for that addictive used for suicide or as a murder weapon.

The serial killer Harold Shipman used diamorphine on his victims, and the subsequent Shipman Finf led to a tightening of the Find Sex Dates - looking for that addictive surrounding the storage, prescribing and destruction of controlled drugs in the UK. John Bodkin Adams is also known to have used heroin as a murder weapon. Because significant tolerance to respiratory depression develops quickly with continued use and is lost just as quickly during withdrawal, it is often difficult to determine whether a heroin lethal overdose was accidental, suicide or homicide.

Chronic use of heroin and other opioids has been shown to be a potential cause of hyponatremiaresultant because of excess vasopressin secretion. Use of heroin by mouth is less common than other methods of administration, mainly because there is little to no "rush", and the effects are less potent. Heroin's oral bioavailability is both dose-dependent as is morphine's and significantly higher than oral use of morphine itself, reaching up to The maximum plasma concentration of morphine following oral administration of heroin was around twice as much as that of oral morphine.

Find Sex Dates - looking for that addictivealso known as "slamming", "banging", "shooting up", "digging" or "mainlining", is a popular Teachey NC milf personals which carries relatively greater risks than other methods of administration.

Heroin base commonly found in Europewhen prepared for injection, will only dissolve in water Girls of pine bluff mixed with an acid most commonly citric acid powder or lemon juice and heated.

Heroin in the east-coast United States is most commonly found in the hydrochloride salt form, requiring just water and no heat to dissolve. Users tend to initially inject in the fr accessible arm veins, but as these veins collapse over time, users resort to more dangerous areas of the body, such as the femoral vein in the groin.

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Users who have used this route of administration often develop a deep vein thrombosis. The dose of heroin used for recreational purposes is dependent on the frequency and level of use: Many countries now supply small sterile spoons and filters for single use in order to prevent the spread of disease. Smoking heroin refers to Fihd it to inhale the resulting fumes, rather than burning and inhaling the smoke.

It is commonly smoked in glass pipes made from glassblown Pyrex tubes and light bulbs. Heroin may be smoked from aluminium foil, which is heated by an Buckland-OH sex dating flame, with the resulting smoke inhaled through a tube of rolled up foil, a method Find Sex Dates - looking for that addictive known as " chasing the dragon ".

Another popular route to intake heroin is insufflation snortingwhere a loojing crushes the heroin into a fine powder and then gently inhales it sometimes with a straw or a rolled-up banknoteas with cocaine into the nose, where heroin is absorbed through the soft tissue in the mucous membrane of the sinus cavity and straight into the bloodstream. This method of administration redirects first-pass metabolismwith a quicker onset and higher bioavailability than oral administration, though the duration of action is shortened.

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This method is sometimes preferred by users who do not want to prepare and administer heroin for injection or smoking, lookig still adcictive a fast onset.

Snorting heroin becomes an often unwanted route, once a user begins to inject the drug. The user may still get high on the drug from snorting, and experience a nod, but will not get a rush. A "rush" is caused by a large amount of heroin entering the body at once.

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When the drug is taken in through the nose, the user does not get the rush because the drug is absorbed slowly rather than instantly. Little research has been focused on the suppository anal insertion Fiind pessary vaginal insertion methods of administration, also known as "plugging".

These methods of administration are commonly carried out using an oral syringe. Heroin can be dissolved and Find Sex Dates - looking for that addictive into an oral syringe which may then be lubricated and inserted into the anus or vagina before the plunger is pushed.

Looking for lover in fuck online rectum or the vaginal canal is where the majority of the drug would likely be taken up, through the membranes lining Find Sex Dates - looking for that addictive walls. Like most opioidsunadulterated heroin may lead to adverse effects. The purity of street heroin varies greatly, leading to overdoses when the purity is higher than they expected.

Users report an intense rushan acute transcendent state of euphoriawhich occurs while diamorphine is being metabolized into 6-monoacetylmorphine 6-MAM and Dstes in the brain.

Some believe that heroin produces more euphoria than other opioids; one possible explanation is the presence of 6-monoacetylmorphine, lookking metabolite unique to heroin — although a more likely explanation is the rapidity of onset.

While other opioids of recreational use produce only morphine, heroin also leaves 6-MAM, also a psycho- active metabolite.

However, this perception is not supported by the results of clinical studies comparing the physiological and subjective effects of injected heroin Find Sex Dates - looking for that addictive morphine in individuals formerly addicted looknig opioids; these subjects showed no preference for one drug over lookimg other. Equipotent injected doses had comparable action courses, with no difference in subjects' self-rated feelings of euphoria, ambition, nervousness, relaxation, drowsiness, or sleepiness.

Nauseavomitingforr severe itching may also occur. After the initial effects, users usually will be drowsy for several hours; mental function is clouded; heart function slows; and breathing is also severely slowed, sometimes enough to be life-threatening. Slowed breathing can also lead to coma and permanent brain damage. Repeated heroin use changes the physical structure and physiology of the brain, creating long-term imbalances in neuronal and hormonal systems that are not easily reversed.

Studies have shown some deterioration of the brain's white matter due to heroin use, which may affect decision-making abilities, the ability to regulate behavior, and responses to stressful situations.

Heroin also produces profound degrees of tolerance and physical dependence. Tolerance occurs when more and more of the drug is required to achieve the same effects. With physical dependencethe body adapts to the presence of the drugand withdrawal symptoms occur if use is reduced abruptly.

Intravenous use of heroin and any other substance with needles and syringes or other related equipment may lead to:. Heroin overdose is usually treated with the opioid antagonistnaloxone. This reverses the effects of heroin and causes an immediate return of consciousness but may result in withdrawal symptoms. The half-life of naloxone is shorter than some opioids, Find Sex Dates - looking for that addictive that it may need to be given multiple times Datee the opioid has been metabolized by the body.

Between and it was the leading cause of drug related deaths in the United States. Depending on drug interactions and numerous other factors, death from overdose can take anywhere from several minutes to several hours. Death usually occurs due to lack of oxygen resulting from the lack of breathing caused by Wife wants casual sex University opioid.

Heroin overdoses can occur because of an unexpected increase in the dose or purity or because of diminished Find Sex Dates - looking for that addictive tolerance. However, many fatalities reported as overdoses are probably caused by interactions with other depressant drugs such as alcohol or benzodiazepines. This means that the Women seeking fuck buddy Indiana may prepare what they consider to be a moderate dose while actually taking far more than intended.